The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway

The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway

Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway...

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Главные авторы: Pei-Cai Fu (Автор), Rong-Hua Tang (Автор), Zhi-Yuan Yu (Автор), Min-Jie Xie (Автор), Wei Wang (Автор), Xiang Luo (Автор)
Формат: article
Опубликовано: Medknow Publications, 2018-01-01T00:00:00Z.
Предметы:
nerve regeneration; spinal cord injury; microglia; ROCK; Y27632; fasudil; migration; morphology; ERK; U0126; in-cell western blot assay; Transwell chambers; neural regeneration
Neurology. Diseases of the nervous system
RC346-429
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