The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

Abstract Background Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway. Methods PJS probands with STK11 mutation were included in the function analysis. P53 activity elevated by STK11 mutants was...

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Main Authors: Yu-Liang Jiang (Author), Zi-Ye Zhao (Author), Bai-Rong Li (Author), Fu Yang (Author), Jing Li (Author), Xiao-Wei Jin (Author), Hao Wang (Author), En-Da Yu (Author), Shu-Han Sun (Author), Shou-Bin Ning (Author)
פורמט: article
יצא לאור: BioMed Central, 2018-08-01T00:00:00Z.
נושאים:
Peutz-Jeghers syndrome (PJS)
STK11 gene
P53 gene
Cancer risk
Reporter gene technique
Internal medicine
RC31-1245
Genetics
QH426-470
article
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